The mutation in the OPA3 gene is assumed to have occurred around 586 B.C. when about 120,000 Jews were exciled to Babylon after the First Temple and Jerusalem were destructed. This created a smaller gene pool because of the genetic isolation, which occurred for 2,500 years. The symptoms of 3-MGA-3 were first noticed in 1909 by Carl Behr who had patients with Behr Syndrome. It is noted that it might have been misdiagnosed because the symptoms of both Behr Syndrome and 3-MGA-3 are very similar. In 1989, Costeff et al., did a study on 19 patients with 3-MGA-3.